IIT Kanpur researchers visualize communication of G-protein coupled receptors and pave way for new drug discovery. 

The study, published in the May issue of the international journal, Molecular Cell, has been conducted using a cutting-edge technology known as cryogenic-electron microscopy (cryo-EM) and has important implications for not only understanding the fundamental mechanism of cellular signaling in our body but it also has potential to facilitate novel drug discovery for several human disease conditions. 

The study, led by Prof. Arun K Shukla, is co-authored by PhD students Mr. Jagannath Maharana, Ms. Parishmita Sarma and Ms. Shirsha Saha, post-doctoral fellows Dr Ramanuj Banerjee and Dr Manish Yadav, project fellows Mr. Sayantan Saha and Mr. Vinay Singh, and includes Dr Mohamed Chami from the University of Basel in Switzerland as a collaborator. 

This study is supported by the DBT Wellcome Trust India Alliance and Science and Engineering Research Board (SERB). 

Journal reference: https://doi.org/10.1016/j.molcel.2023.04.025